The α(2A)-adrenoceptor agonist guanfacine improves spatial learning but not fear conditioning in rats / 生理学报
Acta Physiologica Sinica
;
(6): 739-744, 2007.
Article
in English
| WPRIM
| ID: wpr-258601
ABSTRACT
It is known that stimulation of the α(2A)-adrenoceptors (α(2A)-ARs) by the selective α(2A)-AR agonist guanfacine produces an important and beneficial influence on prefrontal cortical (PFC) cognitive functions such as spatial working memory and selective attention. However, it is unclear whether stimulation of the α(2A)-ARs has a similar effect on fear conditioning that involves the amygdala and hippocampus. Here, we show that systemically administered guanfacine significantly enhances spatial learning of rats in the Lashley maze compared with controls, the rats treated with guanfacine required significantly fewer trials and made significantly fewer errors to reach learning criterion. However, guanfacine produced no effect on acquisition of contextual and auditory fear memories. The present study suggests that beneficial effect of α(2A)-AR stimulation is task-dependent guanfacine improves spatial learning but not fear conditioning.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Spatial Behavior
/
Behavior, Animal
/
Guanfacine
/
Maze Learning
/
Conditioning, Psychological
/
Fear
/
Adrenergic alpha-2 Receptor Agonists
/
Memory
Limits:
Animals
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2007
Type:
Article
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