Effects of beta-cypermethrin on voltage-gated potassium channels in rat hippocampal CA3 neurons / 生理学报
Acta Physiologica Sinica
;
(6): 63-70, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-258687
ABSTRACT
The effects of beta-cypermethrin (consisting of alpha-cypermethrin and theta-cypermethrin) on the transient outward potassium current (I(A)) and delayed rectifier potassium current (I(K)) in freshly dissociated hippocampal CA3 neurons of rats were studied using whole-cell patch-clamp technique. The results indicated that alpha-cypermethrin increased the value of I(A) and theta-cypermethrin decreased the value of I(A), though both of them shifted steady activation curve of I(A) towards negative potential. theta-cypermethrin contributed to the inactivation of I(A). The results also showed that alpha-cypermethrin and theta-cypermethrin decreased the value of I(K), and shifted the steady state activation curve of I(K) towards negative potential. Both alpha-cypermethrin and theta-cypermethrin had no obvious effects on the inactivation of I(K). theta-cypermethrin prolonged recovery process of I(K). These results imply that both transient outward potassium channels and delayed rectified potassium channels are the targets of beta-cypermethrin, which may explain the mechanism of toxical effects of beta-cypermethrin on mammalian neurons.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Pyrethrins
/
Cells, Cultured
/
Rats, Wistar
/
Patch-Clamp Techniques
/
Cell Biology
/
Potassium Channels, Voltage-Gated
/
Toxicity
/
CA3 Region, Hippocampal
/
Insecticides
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2007
Type:
Article
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