Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 448-451, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-258711
ABSTRACT
<p><b>OBJECTIVE</b>To study the inhibition effect of grape procyanidin (GPC) on the cell apoptosis and injury of proliferation induced by radiation.</p><p><b>METHODS</b>Three indices including apoptosis rate, proliferation rate and expression of bcl-2 and bax protein were examined in the mice pancreas after taking different dose GPC by mouth and radiation by (60)Co-gamma ray once.</p><p><b>RESULTS</b>The cell proliferation and bcl-2 expression in high dose GPC group (3.16% +/- 0.13% and 49.8% respectively), were higher than those in radiation control group (0.64% +/- 0.11%, 29.7%), but the cell apoptosis rate and bax expression (19.8% and 55.0% respectively), were lower than those in radiation control group (35.6%, 85.7%). All the above differences were statistically significant (P < 0.05).</p><p><b>CONCLUSION</b>GPC has certain protective effect against the mice pancreatic cell apoptosis and the abnormal expression of bcl-2 and bax protein induced by (60)Co-gamma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreas
/
Pharmacology
/
Radiation Effects
/
Catechin
/
Chemistry
/
Proto-Oncogene Proteins
/
Apoptosis
/
Proto-Oncogene Proteins c-bcl-2
/
Vitis
/
Cell Biology
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2004
Type:
Article
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