Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 413-415, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-258722
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between heat stress proteins 70 (HSPs70) gene polymorphism and the risk of acute mountain sickness.</p><p><b>METHODS</b>Fifty-six soldiers with acute mountain sickness and 173 soldiers without that were chosen as cases and controls. HSP70-1, HSP70-2 genotypes were analyzed by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.</p><p><b>RESULTS</b>The HSP70-1 polymorphism was similar in two groups. The genotype frequency of HSP70-2 B/B in acute mountain sickness group (23.2%) was significantly higher than that in the control (6.9%, P < 0.05, OR = 4.02).</p><p><b>CONCLUSION</b>There is a significantly increased association of HSP70-2 B/B genotype with the risk of acute mountain sickness. Individuals with HSP70-2 B/B genotype may have weaker adaptive ability than those without this genotype under altitude stress. The results contribute to provide scientific bases for finding these individuals in specified occupational people, ensuring their health and enhancing work efficiency.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Acute Disease
/
Epidemiology
/
HSP70 Heat-Shock Proteins
/
Altitude
/
Altitude Sickness
/
Genetics
/
Genotype
Type of study:
Etiology study
Limits:
Adolescent
/
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2004
Type:
Article
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