Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 453-456, 2016.
Article
in English
| WPRIM
| ID: wpr-258800
ABSTRACT
The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization. Toxicity endpoints of mortality, spontaneous movement, heart rate, hatching rate, malformation, body length, and larval behavior were measured. CORM-3 disrupted the progression of zebrafish larval development at concentrations exceeding 50 μmol/L, resulting in embryonic developmental toxicity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organometallic Compounds
/
Pharmacology
/
Zebrafish
/
Carbon Monoxide
/
Cardiotonic Agents
/
Embryology
/
Embryonic Development
/
Dose-Response Relationship, Drug
/
Embryo, Nonmammalian
/
Toxicity
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS