Circulating MicroRNA-21 is Downregulated in Patients with Metabolic Syndrome / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 385-389, 2016.
Article
in English
| WPRIM
| ID: wpr-258808
ABSTRACT
The microRNA-21 (miR-21) is known to play a major role in cancer progression; however, its function in the cardiovascular system appears to be even more complex and conflicting. To characterize miR-21 expression in the plasma of individuals with or without metabolic syndrome (MetS), 58 MetS cases and 96 non-MetS controls were investigated. Expression levels of miR-21 were significantly decreased in the circulation of MetS subjects (OR=0.52, 95% CI 0.29-0.92) compared with that of non-MetS subjects. Body mass index (BMI) and the number of MetS components had a negative correlation with the level of miR-21, whereas age was inversely related to the level of miR-21. No significant difference was detected in miR-21 levels between the sexes (P=0.056). MiR-21 might be a negative regulating factor in MetS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Down-Regulation
/
Risk Factors
/
Reverse Transcriptase Polymerase Chain Reaction
/
Metabolic Syndrome
/
MicroRNAs
/
Real-Time Polymerase Chain Reaction
/
Genetics
/
Metabolism
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2016
Type:
Article
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