Toxic Effects of Tetrabromobisphenol A on Thyroid Hormones in SD Rats and the Derived-reference Dose / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 295-299, 2016.
Article
in English
| WPRIM
| ID: wpr-258820
ABSTRACT
The present study determined the thyroid hormone interference of tetrabromobisphenol A (TBBPA) in Sprague-Dawley (SD) rats, and the derived-reference dose (RfD) of different endpoint effects on mammals based on experimental results and data collection. Based on repeated exposure toxicity tests on mammals and extensive research, the present study used BMDS240 Software to derive a benchmark dose, and analyzed the accuracy and uncertainty, and similarity with other studies. Test results on triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) demonstrated that all the indicators presented a non-monotonous dose-effect relationship clearly, except TSH in male rats exposed to 0-1000 mg/kg BW per day. Therefore, RfDs were derived from different critical effects. In summary, RfD for mammals in the present study was found to be 0.6 mg/kg per day.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Hormones
/
Thyroxine
/
Triiodothyronine
/
Thyrotropin
/
Rats, Sprague-Dawley
/
Polybrominated Biphenyls
/
Dose-Response Relationship, Drug
/
Toxicity
/
Metabolism
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2016
Type:
Article
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