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Protective Effects of Lycopene on Furan-treated Diabetic and Non-diabetic Rat Lung / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 143-147, 2016.
Article in English | WPRIM | ID: wpr-258842
ABSTRACT
We assessed the effects of furan and lycopene on the histopathological and biochemical changes on lungs, body and lung weights, and food consumption of rats. Furan and diabetes caused histopathological changes, increment in malondialdehyde levels, and decrease in antioxidant enzyme activities. Lycopene showed a protective effect against these damages, except for glutathione-S-transferase and glutathione peroxidase activities. Consequently, furan and diabetes resulted in lung toxicity. Our findings demonstrate that furan treatment resulted in more alterations in histology and biochemical parameters in diabetic rats and lycopene showed protective effects against these alterations.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Carotenoids / Rats, Wistar / Diabetes Mellitus, Experimental / Toxicity / Furans / Lung / Antioxidants Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Carotenoids / Rats, Wistar / Diabetes Mellitus, Experimental / Toxicity / Furans / Lung / Antioxidants Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2016 Type: Article