Genetic basis of systemic sclerosis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 97-102, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-259064
ABSTRACT
Systemic sclerosis (SSc) is a connective tissue disease characterized by extensive fibrosis, vasculopathy, and activation of the immune system. Its pathogenesis and mechanisms have not been identified. Studies have shown that environmental and genetic factors are involved in the pathogenesis and development of SSc. Although the concordance for the disease among identical twins is low, concordance for antoantibodies associated with SSc and for fibroblast gene expression profiles is higher. However, the candidate-gene approach has not established clear associations between polymorphisms and SSc. Based on the involvement of SSc, the candidate gene can be screened from three groups fibrosis, immune response, and vascular disease. This article summarizes the recent advances in these three aspects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Scleroderma, Systemic
/
Tumor Necrosis Factor-alpha
/
Protein Tyrosine Phosphatases
/
Genetic Predisposition to Disease
/
Fibrillins
/
Genetics
/
Microfilament Proteins
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS