Histopathological findings of primary cutaneous lichenoid and macular amyloidosis / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the histopathological findings of primary cutaneous lichenoid amyloidosis (LA) and macular amyloidosis (MA).</p><p><b>METHODS</b>The pathological features of 82 patients with primary cutaneous amyloidosis (PCA) admitted from 2003 to 2008 were summarized.</p><p><b>RESULTS</b>There were 52 cases (63%) of LA and 30 cases (37%) of MA, among which 49 cases (60%) presented with pyknotic nucleus of the basal keratinocytes above the amyloid in the upper dermis and 18 cases (22%) presented with pagetoid dyskeratosis (PD) cells among their prickle cells. More amyloid in LA and more severe incontinent of pigment in MA. The deposition level of amyloid protein was significantly higher in patients with LA and the incontinent of pigment was significantly higher in patients with MA (P < 0.01).</p><p><b>CONCLUSION</b>The amyloid protein may be derived from the apoptotic keratinocytes.</p>