Relationship between genetic polymorphisms of interferon-gamma gene intron 1 +874 site and recurrent Condyloma acuminata / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relationship between the polymorphisms of interferon-gamma (IFN-gamma) gene intron 1 at position + 874 and Condyloma Acuminata (CA).</p><p><b>METHODS</b>IFN-gamma gene single nucleotide polymorphisms (intron 1 at position + 874) were detected in 156 subjects, including 76 patients with recurrent CA (CA group) and 80 healthy controls (control group), by polymerase chain reaction with sequence specific primers.</p><p><b>RESULTS</b>No significant difference of IFN-gamma 1 + 874 was found between CA group (TT, TA, and AA frequencies were 10.5%, 34.2%, and 55.3%, respectively) and control group (TT, TA, and AA frequencies were 7.5%, 30.0%, and 62.5%, respectively) (chi2 = 0.959, P = 0.619).</p><p><b>CONCLUSION</b>IFN-gamma gene polymorphism (intron 1 at position + 874) is not correlated with recurrent CA.</p>