Neuronal plasticity of otolith-related vestibular system / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 741-746, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-259090
ABSTRACT
This review focuses on our effort in addressing the development and lesion-induced plasticity of the gravity sensing system. After severance of sensory input from one inner ear, there is a bilateral imbalance in response dynamics and spatial coding behavior between neuronal subpopulations on the two sides. These data provide the basis for deranged spatial coding and motor deficits accompanying unilateral labyrinthectomy. Recent studies have also confirmed that both glutamate receptors and neurotrophin receptors within the bilateral vestibular nuclei are implicated in the plasticity during vestibular compensation and development. Changes in plasticity not only provide insight into the formation of a spatial map and recovery of vestibular function but also on the design of drugs for therapeutic strategies applicable to infants or vestibular disorders such as vertigo and dizziness.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Otolithic Membrane
/
Vestibule, Labyrinth
/
Neuronal Plasticity
/
Neurons
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2008
Type:
Article
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