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Intranasal administration of low dosage recombinant human erythropoietin inhibits seizure in rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 565-571, 2009.
Article in Chinese | WPRIM | ID: wpr-259265
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of intranasal administration of low dosage recombinant human erythropoietin (r-HuEPO) on seizure in rats.</p><p><b>METHODS</b>After intranasal or intraperitoneal administration of r-HuEPO, the behavioral and electroencephalographic changes were observed in pentylenetetrazol (PTZ) and maximal electroshock (MES) induced seizure or electrical amygdaloid-kindled seizure of rats.</p><p><b>RESULT</b>Intranasal administration of low dosage r-HuEPO increased the seizure latency, and decreased the seizure grade and duration, and the number of convulsive episodes in PTZ induced seizure, with the most potential dosage of 2.4 IU. Intraperitoneal administration of r-HuEPO (3 000, 4 000 IU/kg) only decreased the seizure duration and number of convulsive episodes. The seizure grade, forelimb or hindlimb extension duration were decreased in MES-induced seizure by intranasal administration of 2.4 IU r-HuEPO. In addition, intranasal administration of 2.4 IU r-HuEPO decreased the seizure grade, generalized seizure duration and afterdischarge in electrical amygdaloid-kindled rats stimulated with generalized seizure threshold.</p><p><b>CONCLUSION</b>Intranasal administration of low dosage r-HuEPO can inhibit the seizure in rats.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pentylenetetrazole / Recombinant Proteins / Administration, Intranasal / Random Allocation / Erythropoietin / Rats, Sprague-Dawley / Drug Therapy / Epilepsy / Anticonvulsants Type of study: Controlled clinical trial Limits: Animals / Humans / Male Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pentylenetetrazole / Recombinant Proteins / Administration, Intranasal / Random Allocation / Erythropoietin / Rats, Sprague-Dawley / Drug Therapy / Epilepsy / Anticonvulsants Type of study: Controlled clinical trial Limits: Animals / Humans / Male Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2009 Type: Article