Effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 559-564, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-259266
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference (CPP) in rats.</p><p><b>METHODS</b>The persistence, extinction and reinstatement of morphine-induced CPP were established.In clobenpropit group three different doses of clobenpropit (2, 5 and 10 microg/rat, i.c.v.) were administered 15 min after morphine (1 mg/kg, i.p.) was injected. In histidine group histidine (100, 200, 500 mg/kg) was given 1 h prior to morphine treatment (1 mg/kg i.p).</p><p><b>RESULT</b>The CPP was reinstated by priming injection of 1 mg/kg morphine. Clobenpropit (5, 10 microg/rat) significantly inhabited the reinstatement by a priming dose of morphine-induced CPP compared with the morphine control group; histidine (100, 200, 500 mg/kg) significantly inhibited the reinstatement in a dose-dependent manner.</p><p><b>CONCLUSION</b>Clobenpropit and histidine inhibit the revival of morphine-induced CPP in a dose dependent manner, indicating that endogenous histamine may inhibit relapse of morphine to some extent.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Substance Withdrawal Syndrome
/
Thiourea
/
Random Allocation
/
Rats, Sprague-Dawley
/
Receptors, Cell Surface
/
Conditioning, Operant
/
Histidine
/
Imidazoles
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2009
Type:
Article
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