Role of thermo TRP channels in cutaneous neurogenic inflammation and itch / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 409-414, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-259290
ABSTRACT
The temperature-sensitive transient receptor potential (TRP) channels, is also called thermo TRP, including TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1, which are expressed in sensory neurons and non-neuronal cells (e.g.keratinocyte, mast cell) of the skin. Thermo TRP channels are activated/sensitized by physical and chemical mediators, which participate in thermosensation and thermoregulation, so that they are key players in pruritus or pain pathogenesis. Thermo TRP channels are also involved in cutaneous neurogenic inflammation, thus they are regarded as molecular targets for future therapy in skin inflammation, pruritus and pain. In addition, following a basic syntax and molecular substrate of nociception and pruriception established by TRP channels-centered concept, the sensory categories can be distinguished and re-defined. Thermo TRP channels should be taken into account when analyzing the pathogenesis and management of itch or pruritic dermatosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Pruritus
/
Sensory Receptor Cells
/
Skin
/
Thermoreceptors
/
Inflammation Mediators
/
Transient Receptor Potential Channels
/
Inflammation
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2009
Type:
Article
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