Novel targets for antibiotics discovery: riboswitches / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1361-1368, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-259468
ABSTRACT
Riboswitches are cis-acting domains located in mRNA sequences that could regulate gene expression by sensing small molecules without employing protein. Most known riboswitches in bacteria have naturally evolved to bind essential metabolite ligands and are involved in the regulation of critical genes that are responsible for the biosynthesis or transport of the cognate ligand. The riboswitch-mediated gene expression could be repressed by metabolite analogs, which caused bacterial growth inhibition or even death. A number of leading compounds targeting riboswitches have been discovered. A promising avenue for the development of new class of riboswitch-based antibiotics has been opened. Herein we reviewed the current findings of riboswitches that served as targets for antibacterial drug development and the underlying mechanisms. The development of high-throughput methods and rational drug design for riboswitch-specific drug discovery are relevant challenges are discussed. summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Thiamine Pyrophosphatase
/
Bacteria
/
Bacterial Proteins
/
Drug Design
/
Gene Expression Regulation, Bacterial
/
Chemistry
/
Drug Discovery
/
High-Throughput Screening Assays
/
Riboswitch
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS