Real-time UV imaging of chloramphenicol intrinsic dissolution characteristics from ophthalmic in situ gel / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1156-1163, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-259499
ABSTRACT
In this paper, chloramphenicol was selected as a model drug to prepare in situ gels. The intrinsic dissolution rate of chloramphenicol from in situ gel was evaluated using the surface dissolution imaging system. The results indicated that intrinsic dissolution rate of chloramphenicol thermosensitive in situ gel decreased significantly when the poloxamer concentration increased. The addition of the thickener reduced the intrinsic dissolution rate of chloramphenicol thermosensitive gel, wherein carbomer had the most impact. Different dilution ratios of simulated tear fluid greatly affected gel temperature, and had little influence on the intrinsic dissolution rate of chloramphenicol from the thermosensitive in situ gel. The pH of simulated tear fluid had little influence on the intrinsic dissolution rate of chloramphenicol thermosensitive in situ gel. For the pH sensitive in situ gel, the dissolution rates of chloramphenicol in weak acidic and neutral simulated tear fluids were slower than that in weak alkaline simulated tear fluid. In conclusion, the intrinsic dissolution of chloramphenicol from in situ gel was dependent on formulation and physiological factors. With advantages of small volume sample required and rapid detection, the UV imaging method can be an efficient tool for the evaluation of drug release characteristics of ophthalmic in situ gel.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ophthalmic Solutions
/
Solubility
/
Spectrophotometry, Ultraviolet
/
Temperature
/
Viscosity
/
Acrylic Resins
/
Chemistry
/
Chloramphenicol
/
Drug Delivery Systems
/
Poloxamer
Type of study:
Prognostic study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article
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