Pharmacokinetics and tissue distribution of irinotecan hydrochloride nanoparticles / 药学学报
Acta Pharmaceutica Sinica
;
(12): 940-945, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-259526
ABSTRACT
To investigate the pharmacokinetics of irinotecan hydrochloride (CPT-11) in rats and the tissue distribution of CPT-11 in mice after injection of irinotecan hydrochloride nanoparticles (CPT-11 NPs) via tail veins, separately, a LC-MS/MS method was established to determine the concentration of CPT-11 in whole blood of rats and in different tissues of mice. The pharmacokinetics and tissue distribution of CPT-11 were compared after the intravenous injection of CPT-11 NPs and CPT-11 solution. Compared with CPT-11 solution, the elimination half-life of CPT-11 was prolonged from 2.28 h to 3.95 h after the intravenous injection of CPT-11 NPs, and its AUC was 1.47 times than that of CPT-11 solution. After the injection of CPT-11 NPs in mice, the concentrations of CPT-11 loaded in CPT-11 NPs were significantly higher in the whole blood, colon and lungs than those in CPT-11 solution, but lower in the spleen, liver, kidney and heart, but the least in brain. CPT-11 NPs could improve CPT-11 's AUC, and help CPT-11 to reach long circulation activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Camptothecin
/
Pharmacokinetics
/
Tissue Distribution
/
Random Allocation
/
Chromatography, High Pressure Liquid
/
Rats, Sprague-Dawley
/
Area Under Curve
/
Spectrometry, Mass, Electrospray Ionization
/
Nanoparticles
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article
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