A new sesquiterpenoid from fungus Colletotrichum sp. and its cytotoxicity / 药学学报
Acta Pharmaceutica Sinica
;
(12): 891-895, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-259534
ABSTRACT
A novel sesquiterpenoid (1) and three known compounds identified as isoaltenuene (2), altenuene (3), and alternariol 4, 10-O-dimethyl ether (4), were isolated in our investigation of the cytotoxic constituents from solid cultures of the endophytic fungus Colletotrichum sp. The structures of these compounds were elucidated through spectroscopic data analysis. All compounds exhibited cytotoxic activity against lung cancer cell line A549, breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC-1. Compound 4 could induce the PANC-1 cells inflation or death, but couldn't induce apoptosis at the IC50 of 60.2 microg x mL(-1).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Sesquiterpenes
/
Molecular Structure
/
Chemistry
/
Apoptosis
/
Colletotrichum
/
Inhibitory Concentration 50
/
Cell Line, Tumor
/
Cell Proliferation
/
Lactones
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article
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