Design, synthesis and antitumor activity of valproic acid salicylanilide esters / 药学学报
Acta Pharmaceutica Sinica
;
(12): 874-880, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-259537
ABSTRACT
A series of valproic acid salicylanilide esters were designed and synthesized based on the principle of prodrug. The structures of the target compounds were confirmed by MS, 1H NMR and 13C NMR. Anti-tumor activities of these compounds against K562, A549, A431 cells in vitro were investigated by MTT assay and SRB assay. The results indicated that the compounds 6h-6j were found to have stronger cell growth inhibitory action than gefitinib, and comparable to niclosamide, which are worth to be intensively studied further.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Salicylanilides
/
Structure-Activity Relationship
/
Prodrugs
/
Drug Design
/
Molecular Structure
/
Chemistry
/
Valproic Acid
/
K562 Cells
/
Inhibitory Concentration 50
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article
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