Mechanism of psoriasis generation in animal models

Hong LI; Jin-Hong HU

Mechanism of psoriasis generation in animal models / 药学学报

Hong LI; Jin-Hong HU.

Acta Pharmaceutica Sinica ; (12): 809-813, 2013.

Article in Chinese | WPRIM | ID: wpr-259546

ABSTRACT

ABSTRACT

Psoriasis is a chronic inflammatory disease related to genome-wide and surroundings, it is important to develop a suitable animal model to research psoriasis pathogenesis and evolve pharmacotherapeutics. With the development of transgenetic technology in the past few years, psoriasis virulence gene animal model become a hotspot. Research of animal model of human psoriasis genes is reviewed in the paper.

Subject(s)

Animals; Humans; Aminoquinolines; Toxicity; Amphiregulin; Disease Models, Animal; EGF Family of Proteins; Genetics; Metabolism; Keratin-14; Genetics; Metabolism; Keratin-5; Genetics; Metabolism; Keratinocytes; Metabolism; Membrane Glycoproteins; Mice, Transgenic; Psoriasis; Genetics; Metabolism; Receptor, TIE-2; Genetics; Metabolism; STAT3 Transcription Factor; Genetics; Metabolism; Toll-Like Receptor 7; Transforming Growth Factor beta1; Genetics; Metabolism

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Psoriasis / Membrane Glycoproteins / Mice, Transgenic / Keratinocytes / Receptor, TIE-2 / Disease Models, Animal / STAT3 Transcription Factor / Toll-Like Receptor 7 / Toxicity / Keratin-14 Type of study: Prognostic study Limits: Animals / Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2013 Type: Article

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