The associations between idiosyncratic adverse drug reactions and HLA alleles and their underlying mechanism / 药学学报
Acta Pharmaceutica Sinica
;
(12): 799-808, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-259547
ABSTRACT
With the advent of Twenty-First century, more and more genome-wide association studies (GWAS) showed that idiosyncratic adverse drug reactions (ADRs) were closely related with human leukocyte antigen (HLA) alleles, such as the associations of abacavir-HLA-B*5701, allopurinol-HLA-B*5801, and carbamazepine-HLA-B*1502, etc. To explore the mechanisms of these idiosyncratic drug reactions, hapten hypothesis, danger signal hypothesis, pharmacological interaction (P-I) concept and autoimmune mechanism are proposed. In this paper, recent GWAS studies on the HLA-mediated adverse drug reactions and underlying mechanism are reviewed in detail.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carbamazepine
/
Dideoxynucleosides
/
HLA-B Antigens
/
Allopurinol
/
Stevens-Johnson Syndrome
/
Anti-HIV Agents
/
Drug-Related Side Effects and Adverse Reactions
/
Alleles
/
Enzyme Inhibitors
/
Allergy and Immunology
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article
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