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Expression Changes of β-catenin and P-GSK-3β in Patients with Mantle Cell Lymphoma / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 407-410, 2015.
Article in Chinese | WPRIM | ID: wpr-259576
ABSTRACT
<p><b>OBJECTIVE</b>This study was purposed to detect the expressions of β-catenin and P-GSK-3 β in Wnt signaling pathway of patients with mantle cell lymphoma(MCL), and investigate its relationship with the pathogenesis of MCL.</p><p><b>METHODS</b>The expression levels of β -catenin protein and P-GSK-3 protein in mantle cell lymphoma and hyperplastic lymphadenitis were detected by using anti-β-catenin, P-GSK-3β polyclonal antibody and S-P staining technique.</p><p><b>RESULTS</b>The abnormal expression of β-catenin protein(73.33%) in mantle cell lymphoma group was significantly higher than that (6.7%) in reactive lymph node hyperplasia group (P<0.05); and the positive rate of P-GSK-3 β(66.67%) in mantle cell lymphoma group was significantly higher than that (16.67%) in reactive hyperplasia of lymph node group (P<0.05). Spearman correlation analysis showed that there was obvious positive correlation (R=0.852, P<0.01).</p><p><b>CONCLUSION</b>The abnormal high expressions of β-catenin and P-GSK-3 β protein have been confirmed to appeare in mantle cell lymphoma.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Lymphoma, Mantle-Cell / Glycogen Synthase Kinase 3 / Beta Catenin / Wnt Signaling Pathway / Glycogen Synthase Kinase 3 beta Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Lymphoma, Mantle-Cell / Glycogen Synthase Kinase 3 / Beta Catenin / Wnt Signaling Pathway / Glycogen Synthase Kinase 3 beta Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2015 Type: Article