Recent advances of studies on abnormal HOX gene in myelodysplastic syndromes and its molecular mechanisms / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 261-265, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-259603
ABSTRACT
HOX gene encodes a group of homeodomain transcription factors which are highly conserved. The caudal-type homeobox (CDX) , ten-eleven translocation (TET) genes and polycomb group (PcG) , trithorax group (TrxG) proteins act as upstream regulators of HOX genes that manipulate the targeted gene expression through genetic and epigenetic mechanisms. The abnormal expression of HOX genes and their fusions contribute to myelodysplastic syndromes (MDS) pathogenesis. Aberrant DNA methylation and NUP98-HOX translocation serve as molecular mediators of dysfunction in MDS which can be used for the evaluation of biology and therapy. This article provides an overview of recent advances of studies on HOX gene and its abnormal molecular mechanisms, as well as potential correlation with MDS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Translocation, Genetic
/
Myelodysplastic Syndromes
/
Genes, Homeobox
/
Drosophila Proteins
/
Epigenesis, Genetic
/
DNA-Binding Proteins
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS