Analysis of prognosis in acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 173-177, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-259619
ABSTRACT
<p><b>OBJECTIVE</b>The study was to investigate the prognosis factors in acute myeloid leukemia (AML) patients treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>The clinical information of 60 patients in our hospital was retrospectively analyzed and the prognosis factors of survival and relapse were explored by COX's proportional hazard model.</p><p><b>RESULTS</b>The elderly (HR = 4.530, P = 0.012), cGVHD (HR = 0.023, P = 0.003) and infection fungal disease (IFD) (HR = 4.019, P = 0.017) were influence factors for 2 year cumulative overall survival (OS). Response status (high risk vs low risk HR = 3.465, P = 0.028), preconditioning regimens (TBI/Cy vs Bu/Cy HR = 0.071, P = 0.012; FB vs Bu/Cy HR = 7.547, P = 0.025) and cGVHD (HR = 0.088, P = 0.004) were influence factors for 2 year cumulative relapse rate (RR). cGVHD (P = 0.017) and IFD (P = 0.000) had an effect on OS after 2 years since allo-HSCT.</p><p><b>CONCLUSION</b>Age, response status, preconditioning regimens, cGVHD and IFD are closely associated with the prognosis of AML patients treated with allo-HSCT, and different patients need the individualized treatment.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Leukemia, Myeloid, Acute
/
Proportional Hazards Models
/
Retrospective Studies
/
Hematopoietic Stem Cell Transplantation
/
Allografts
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2015
Type:
Article
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