Diagnostic value of hepcidin in elderly patients with iron deficiency anemia and anemia of chronic disease / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 155-158, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-259622
ABSTRACT
<p><b>OBJECTIVE</b>This study was to evaluate the differential diagnostic value of serum Hepcidin in elderly patients with iron deficiency anemia (IDA)and anemia of chronic disease (ACD).</p><p><b>METHODS</b>The group of IDA consisted of 28 elderly patients, and the group of ACD consisted of 21 elderly patients, the control group included 25 healthy elderly people. Hepcidin was measured by ELISA; WBC,RBC counts were assayed by haematology analyzer; the serum ferritin level was measured by using radioimmunoassay; C-reaction protein(CRP) and serum iron levels were assayed by a biochemical analyzer.</p><p><b>RESULTS</b>Hepcidin level between the three groups was significantly different (P < 0.01); serum ferritin,WBC and CRP levels in ACD patients were significantly higher than that in IDA patients (P < 0.01); according to the receivers operating characteristic (ROC) curve, the best threshold in diagnosis of IDA was 93.31 µg/L with the sensitivity of 88% and the specificity of 89%; the best threshold diagnosis of ACD was 130.05 µg/L with the sensitivity of 72% and the specificity of 96%.</p><p><b>CONCLUSIONS</b>serum Hepcidin has a certain value in the differential diagnosis of IDA and ACD in elderly patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Carrier Proteins
/
Chronic Disease
/
Sensitivity and Specificity
/
Anemia, Iron-Deficiency
/
Diagnosis, Differential
/
Erythrocyte Count
/
Hepcidins
/
Anemia
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Aged
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2015
Type:
Article
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