Research on amplitude of low-frequency fluctuation in patients with major depression based on resting-state functional magnetic resonance imaging / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 97-102, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-259689
ABSTRACT
We investigated the baseline brain activity level in patients with major depressive disorder (MDD) by am plitude of low-frequency fluctuation (ALFF) based on resting-state functional MRI (fMRI). We examined 13 patients in the MDD group and 14 healthy volunteers in the control group by resting-state fMRI on GE Signa 3.0T. We calculated and compared the ALFF values of the two groups. In the MDD group, ALFF values in the right medial prefrontal were higher than those in control group, with statistically significant differences (P < 0.001). ALFF values in the left parietal in the MDD group were lower than those in control group with statistically significant differences (P < 0.001). This resting-state fMRI study suggested that the alteration brain activity in the right medial prefrontal and left parietal ALFF contributed to the understanding of the pathophysiological mechanism of MDD patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Brain Mapping
/
Magnetic Resonance Imaging
/
Case-Control Studies
/
Depressive Disorder, Major
Type of study:
Observational study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2014
Type:
Article
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