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Effect of Low Dose 5-Fluorouracil and Cisplatin Intra-arterial Infusion Chemotherapy in Advanced Hepatocellular Carcinoma with Decompensated Cirrhosis / 대한간학회지
The Korean Journal of Hepatology ; : 65-73, 2006.
Article in Korean | WPRIM | ID: wpr-25989
ABSTRACT
BACKGROUND/

AIMS:

Advanced hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) has a poor prognosis. The aim of this study was to evaluate the efficacy and safety of repeated arterial infusions of low dose cisplatin and 5-fluorouracil (FU) in patients with advanced HCC with decompensated cirrhosis.

METHODS:

Between January 1995 and December 2003, a total of 79 decompensated cirrhotic patients having HCC and PVT were enrolled and divided into 2 groups. Group 1 (n=40) received intra-arterial infusion chemotherapy with cisplatin (10 mg for 5 days) and 5-FU (250 mg for 5 days) via an implanted chemoport every 4 weeks' and group 2 (n=39) was managed with only conservative treatment.

RESULTS:

The two groups were well matched with respect to the features relating to the prognosis, including age, gender and the Child- Pugh class. Although diffuse tumor involvement, main portal vein tumor thrombosis and bi-lobar involvement were more frequent in group 1, the median survival period of group 1 was significantly longer than group 2 (5 months vs. 3 months, respectively, P=0.016). Also, the 1-year survival rate of group 1 (7.5%) was higher than that of group 2 (5.1%) (P=0.016). When we analyzed the patients with the Child class B, the survival benefits of intra-arterial chemotherapy were more significant (P=0.008).

CONCLUSIONS:

Intra-arterial chemotherapy consisting of low dose 5-FU and cisplatin achieved favorable results for advanced HCC patients who had decompensated cirrhosis, and it showed better survival in selected patients. This therapy may be useful as a palliative treatment for HCC patients with decompensated cirrhosis.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Palliative Care / Portal Vein / Infusions, Intra-Arterial / Antineoplastic Combined Chemotherapy Protocols / Survival Rate / Cisplatin / Carcinoma, Hepatocellular / Disease-Free Survival / Venous Thrombosis / Fluorouracil Limits: Adult / Aged / Female / Humans / Male Language: Korean Journal: The Korean Journal of Hepatology Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Palliative Care / Portal Vein / Infusions, Intra-Arterial / Antineoplastic Combined Chemotherapy Protocols / Survival Rate / Cisplatin / Carcinoma, Hepatocellular / Disease-Free Survival / Venous Thrombosis / Fluorouracil Limits: Adult / Aged / Female / Humans / Male Language: Korean Journal: The Korean Journal of Hepatology Year: 2006 Type: Article