Expression and significance of P311 and ITGB4BP in non-small cell lung cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 526-528, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-260361
ABSTRACT
<p><b>OBJECTIVE</b>The aim of this study was to investigate the expression and significance of P311 and ITGB4BP in non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>Tissue microarrays were prepared from 80 NSCLC specimens and examined by immunohistochemistry.</p><p><b>RESULTS</b>The positive rates of P311 and ITGB4BP expression were 77.5% (62/80) and 82.5% (66/80), respectively. The double positive expression rate was 73.8% (59/80). The consistency rate was 87.5%, and there was a significant consistency between P311 and ITGB4BP expressions (Kappa = 0.611, P < 0.001).</p><p><b>CONCLUSION</b>There may be a new signaling pathway P311-ITGB4BP in NSCLC, and it may regulate the lung cancer cell migration.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Signal Transduction
/
Paraffin Embedding
/
Oncogene Proteins
/
Carcinoma, Non-Small-Cell Lung
/
Eukaryotic Initiation Factors
/
Tissue Array Analysis
/
Lung Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2010
Type:
Article
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