Expression of E-cadherin in nasopharyngeal carcinoma and its relationship with cervical lymph node metastasis / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 425-428, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-260386
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of E-cadherin in nasopharyngeal carcinoma (NPC) and its relationship with cervical lymph node metastasis.</p><p><b>METHODS</b>The expression of E-cadherin in 80 patients with NPC was detected by immunohistochemistry.</p><p><b>RESULTS</b>Lower expression of E-cadherin was associated with advanced N-stage of the tumor (P = 0.018). There was no significant correlation between the expression of E-cadherin and lymph node size (P = 0.435). The expression of E-cadherin was higher in patients with cervical lymph node metastasis limited to a single area than that distributing in some scattered areas (P = 0.000). There was a trend that the expression of E-cadherin in the cases with the tumor and lymph nodes in the same side was higher (56.5%) than that in the patients with bilateral lymph node metastases (32.6%), however, the difference was not significant (P = 0.059). The expression rates of E-cadherin in patients with lymph node metastasis in levels II, III and Va were higher than that in levels I, IV, Vb and VI, but with a non-significant difference (P = 0.059).</p><p><b>CONCLUSION</b>The expression of E-cadherin has influence on the lymph node metastasis in nasopharyngeal carcinoma. E-cadherin expression is negatively correlated with the numbers of the lymph node metastases and the metastasis distance, i.e. a lower expression of E-cadherin leads to an advanced N-stage. The lymph node metastasis of nasopharyngeal cancer from above to below is more considerably influenced by E-cadherin expression than the metastasis towards contralateral lymph nodes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Carcinoma, Squamous Cell
/
Cadherins
/
Nasopharyngeal Neoplasms
/
Lymph Nodes
/
Lymphatic Metastasis
/
Metabolism
/
Neoplasm Staging
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2010
Type:
Article
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