The Effects on the MSG with Phenylalanine Treatment in the Area Postrema of the Rat Medulla / 체질인류학회지
Korean Journal of Physical Anthropology
;
: 213-220, 2000.
Article
in Korean
| WPRIM
| ID: wpr-26042
ABSTRACT
Glutamate is an amino acid neurotransmitter capable of producing widespread receptor-mediated neuronal excitation. In this experiment, we examined the effect of saline, monosodium glutamate (MSG), phenylalanine and MSG-phenylalanine treatment on TH immunoreactivity in area postrema (AP) of medulla oblangata. An immunocytochemical method was used to visualize catecholaminergic neurons in the AP. Damage of TH neurons in the AP of adult Sprague-Dawley rats was induced by injection of MSG (4 mg/g bw) and was decreased by administration of MSG following phenylalanine treatment (15 mg/g bw). We conclude that phenylalanine protect from the neuroexcitotoxic effect of systemic glutamate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylalanine
/
Sodium Glutamate
/
Rats, Sprague-Dawley
/
Neurotransmitter Agents
/
Glutamic Acid
/
Area Postrema
/
Neurons
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Physical Anthropology
Year:
2000
Type:
Article
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