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Changes of antigen-specific cytotoxic T lymphocytes during acute flare-ups in chronic hepatitis B patients / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 721-724, 2006.
Article in Chinese | WPRIM | ID: wpr-260616
ABSTRACT
<p><b>OBJECTIVE</b>To detect HBV antigen specific cytotoxic T lymphocyte (CTL) changes in patients during acute flare-ups and to study their association with flare-ups and aggravations into grave hepatitis by quantitative analysis of HLA-A2* restricted HBcAg-specific CTL cells.</p><p><b>METHODS</b>The frequency of HBcAg-specific CTL cells in the peripheral blood mononuclear cells (PBMC) from 29 patients with persistent infection with HBV were quantified by flow cytometry using one HLA-A2*HBV peptide pentamers complex (Pro5TM MHC Pentamers).</p><p><b>RESULTS</b>There was a statistical difference of HBcAg specific CTLs between the patients with acute exacerbations (1.4%+/-0.8%) and the patients with immune tolerance (0.6%+/-0.4%) (t = 2.180, P = 0.01-0.05); There was no significant difference between the grave hepatitis group (1.3%+/-1.0%) and the chronic hepatitis group (1.4%+/-0.8%) regarding frequencies of antigen specific CTL (t = 0.215, P = 0.833-0.05). The level of antigen specific CTLs in PBMC in the 6 cases of chronic hepatitis B with acute exacerbations maintained a relatively high level (more than 0.7%) within the 12 week follow-up period.</p><p><b>CONCLUSION</b>HBcAg-specific CTLs may play an important role in hepatic flare-ups in patients with chronic HBV infection, but there was no direct relationship between antigen- specific CTLs and grave hepatitis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Virology / T-Lymphocytes, Cytotoxic / HLA-A2 Antigen / Hepatitis B virus / Viral Load / Hepatitis B, Chronic / Allergy and Immunology / Hepatitis B Core Antigens Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hepatology Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Virology / T-Lymphocytes, Cytotoxic / HLA-A2 Antigen / Hepatitis B virus / Viral Load / Hepatitis B, Chronic / Allergy and Immunology / Hepatitis B Core Antigens Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hepatology Year: 2006 Type: Article