Study on transdermal absorption of piperine in Erxiekang plaster / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To research the absorbed character of piperine in Erxiekang plaster, and piperine by transdermal absorption was determined.</p><p><b>METHOD</b>The percutaneous absorption of piperine in vitro at different times was conducted by Franz osmosis and diffusion apparatus as well as high-performance liquid chromatography.</p><p><b>RESULT</b>It showed that the piperine through skins of mice gradually increased within the experiment time. After 52 h, the penetration of piperine was 78.51%, and remained basically unchanged.</p><p><b>CONCLUSION</b>The method is reliable, and can be used for Erxiekang plaster of determination of transdermal absorption.</p>