Study on transdermal absorption of piperine in Erxiekang plaster / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3294-3296, 2010.
Article
in Zh
| WPRIM
| ID: wpr-260668
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To research the absorbed character of piperine in Erxiekang plaster, and piperine by transdermal absorption was determined.</p><p><b>METHOD</b>The percutaneous absorption of piperine in vitro at different times was conducted by Franz osmosis and diffusion apparatus as well as high-performance liquid chromatography.</p><p><b>RESULT</b>It showed that the piperine through skins of mice gradually increased within the experiment time. After 52 h, the penetration of piperine was 78.51%, and remained basically unchanged.</p><p><b>CONCLUSION</b>The method is reliable, and can be used for Erxiekang plaster of determination of transdermal absorption.</p>
Full text:
1
Index:
WPRIM
Main subject:
Piperidines
/
Skin Absorption
/
Linear Models
/
Reproducibility of Results
/
Rats, Sprague-Dawley
/
Alkaloids
/
Benzodioxoles
/
Polyunsaturated Alkamides
/
Metabolism
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Type:
Article