Influence of suoquan capsule on detrusor of D-galactose mimetic rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3207-3210, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-260719
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the influence of Suoquan capsule (SQJN) on the detrusor of D-galactose mimetic rats, and to explore the mechanism of reducing urine.</p><p><b>METHOD</b>Investigate the enzymes (ATPase, SDH, SOD, MDA, Na+ -K+ -ATPase, Ca2+ - Mg2+ -ATPase) which influence the production and excretion of urine and the reactivity of urinary detrusor strips to different concentrations of ISO and ATP.</p><p><b>RESULT</b>Compared with the model group, the activity of SOD, Na+ -K+ -ATPase, Ca2+ -Mg2+ -ATPase and SDH increased significantly in aging rats after administrating SQJN (P < 0.01); the complaisance and elasticity of bladder also increased (P < 0.05). The frequency of spontaneous contraction and the MDA decreased significantly (P < 0.05-0.01). The decreased relaxation response to ISO and increased contractile response to ATP were also changed after administrating SQJN.</p><p><b>CONCLUSION</b>SQJN can regulate the metabolism of fluid through recovering the normal physiologic function of the detrusor of bladder.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Urination
/
Urinary Bladder
/
Drugs, Chinese Herbal
/
Disease Models, Animal
/
Drug Therapy
/
Urinary Incontinence, Urge
/
Galactose
/
Metabolism
/
Muscle Contraction
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Type:
Article
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