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Influence of suoquan capsule on detrusor of D-galactose mimetic rats / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3207-3210, 2010.
Article in Chinese | WPRIM | ID: wpr-260719
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the influence of Suoquan capsule (SQJN) on the detrusor of D-galactose mimetic rats, and to explore the mechanism of reducing urine.</p><p><b>METHOD</b>Investigate the enzymes (ATPase, SDH, SOD, MDA, Na+ -K+ -ATPase, Ca2+ - Mg2+ -ATPase) which influence the production and excretion of urine and the reactivity of urinary detrusor strips to different concentrations of ISO and ATP.</p><p><b>RESULT</b>Compared with the model group, the activity of SOD, Na+ -K+ -ATPase, Ca2+ -Mg2+ -ATPase and SDH increased significantly in aging rats after administrating SQJN (P < 0.01); the complaisance and elasticity of bladder also increased (P < 0.05). The frequency of spontaneous contraction and the MDA decreased significantly (P < 0.05-0.01). The decreased relaxation response to ISO and increased contractile response to ATP were also changed after administrating SQJN.</p><p><b>CONCLUSION</b>SQJN can regulate the metabolism of fluid through recovering the normal physiologic function of the detrusor of bladder.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Urination / Urinary Bladder / Drugs, Chinese Herbal / Disease Models, Animal / Drug Therapy / Urinary Incontinence, Urge / Galactose / Metabolism / Muscle Contraction Limits: Animals / Female / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Urination / Urinary Bladder / Drugs, Chinese Herbal / Disease Models, Animal / Drug Therapy / Urinary Incontinence, Urge / Galactose / Metabolism / Muscle Contraction Limits: Animals / Female / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2010 Type: Article