Study on novel colon position pulsatile capsule and its release in vitro / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3127-3130, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-260739
ABSTRACT
<p><b>OBJECTIVE</b>To develop a colon position pulsatile capsule drug delivery system of which the lag-time is controlled by a plug tablet mainly made of konjac glucomannan and evaluate its release profile in vitro.</p><p><b>METHOD</b>Impermeable capsule body was prepared by filling method, the plug tablet was pressed by direct compression, and the rapid-disintegrable drug tablets was made by wet granulation. The pulsatile capsules were prepared by putting the drug tablet into the impermeable body and sealed it with the plug tablet The factors affecting the lag-time were investigated by dissolution testing.</p><p><b>RESULT</b>The formulation of the rapid-disintegrable drug tablets influenced the pulsatile release of the drug, the composition of the plug tablet significantly influenced the lag-time; the lag-time was extended with the higher viscosity of HPMC and the increased proportion of konjac glucomannan.</p><p><b>CONCLUSION</b>The pulsatile capsule with a suitable lag-time and colon position characteristics can be achieved by adjusting the composition of the plug tablet.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Capsules
/
Pharmacokinetics
/
Chemistry
/
Technology, Pharmaceutical
/
Drug Delivery Systems
/
Colonic Diseases
/
Mesalamine
/
Therapeutic Uses
/
Drug Therapy
/
Mannans
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Type:
Article
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