Advancement of studies on ALDH1 as a universal marker of stem cells / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1183-1186, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-260913
ABSTRACT
Aldehyde dehydrogenase 1 (ALDH1, ALDH1A1 or RALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, was shown to have a function in the early differentiation of stem cells. Its activity shows promising potential as a universal marker for the identification and isolation of normal stem cells and cancer stem cells from multiple sources in a variety of tissue types. Herein, we review the available data reporting the utilization of ALDH1 activity as a means to identify and isolate normal stem cells and cancer stem cells (CSCs), and the potential diagnostic and therapeutic implications, with a special focus on the mammary gland and breast cancer. The research opportunity in this area of interest is emphasized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Neoplastic Stem Cells
/
Biomarkers
/
Biomarkers, Tumor
/
Retinal Dehydrogenase
/
Isoenzymes
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2010
Type:
Article
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