Study of the correlation between 51 immune infertility patients of the Han nationality in Anhui and HLA-DQA1 gene and treatment of Mianbu III / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 334-337, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-260994
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation between anti-sperm antibody-positive immune infertility patients and human leucocyte antigen (HLA) DQA1 gene, and to study the correlation between the treatment of Chinese medicine and pharmacy and HLA-DQA1 genotype.</p><p><b>METHODS</b>The polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used in studying HLA-DQA1 genotypes of 51 anti-sperm antibody-positive immune infertility patients and 60 healthy subjects. Mianbu III (consisting of rehmannia root, white peony root, Fructus Comi, yam, barbary wolfberry fruit, moutan bark, and dwarf lilyturf root) was used in patients for three months.</p><p><b>RESULTS</b>The HLA-DQA1 *0401 allele in the immune infertility group was obviously higher than that in the healthy control group (chi2 = 29.869, P < 0.01). As for the therapeutic efficacy 22 cases of the 27 positive HLA-DQA1 * 0401 turned to negative with statistical difference (chi2 = 5.24, P = 0.022).</p><p><b>CONCLUSION</b>HLA-DQA1 *0401 allele might be predisposing gene of the anti-sperm antibody-positive immune infertility. The Chinese medicinal treatment was effective for the HLA-DQA1 *0401 allele patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Case-Control Studies
/
Genetic Predisposition to Disease
/
Therapeutic Uses
/
Asian People
/
Drug Therapy
/
Alleles
/
HLA-DQ alpha-Chains
/
Gene Frequency
/
Genetics
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS