Effects of sanren decoction on plasma lipids and the metabolic profiles of hyperlipidemia rat model / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of Sanren Decoction and its separated recipe on the plasma lipids and metabolic profiles of hyperlipidemia rat model.</p><p><b>METHODS</b>The hyperlipidemia rat model was established by feeding with high fat diet. Male Wistar rats were randomly divided into the normal control group (normal group), model group, the Shangjiao group, the Zhongjiao group, the Xiajiao group, Sanren group and Atorvastatin calcium group (control group), 10 in each. Sanren Decoction, a representative recipe based on the Sanjiao theory, and the various combinations of its components based on its compatibility principle were selected. The changes in plasma lipids and metabolic profiles of the model rats were then observed using biochemical methods and NMR-based metabonomic techniques.</p><p><b>RESULTS</b>Significant hypercholesterolemia was observed in model rats after three weeks by feeding with high fat diet (P < 0.05). Compared with the model group, Sanren Decoction and its separated components reduced plasma cholesterol to various degrees (P < 0.05, P < 0.01). Besides, Sanren Decoction had better effect than the Shangjiao group (P < 0.05). The metabolic profiles of the model rats were different from those of the control groups, the Sanren Decoction group and the three separated components groups. The effect of Sanren Decoction on the model group was better than each separated recipe group. The results demonstrated that the effect on improving the blood lipid levels by overall regulation of Sanjiao was better than those by the regulation of Shangjiao, Zhongjiao or Xiajiao respectively.</p><p><b>CONCLUSIONS</b>The Sanjiao theory is useful in guiding the treatment of hyperlipidemia.</p>