Autophagy and its relationship with tumor proliferation, invasion, and treatment / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 98-103, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-261129
ABSTRACT
Autophagy is a highly conservative biological behavior in eukaryotic cells. This dynamic process involves "wrapping" cytoplasmic components and combining with lysosomes in cells for catabolism. The catabolic effect of autophagy can eliminate toxic substances in cells, maintain homeostasis in the intracellular environment, and produce small molecules, such as amino acids, which nourish cells, thereby allowing them to survive. Autophagy can inhibit the occurrence of tumors by maintaining homeostasis in the intracellular environment. However, it can promote the proliferation, invasion, and metastasis of malignant tumor cells. Autophagy can regulate the microenvironment of tumor cells and has an important role in a series of processes, such as anoikis, tumor dormancy, and epithelial-mesenchymal transition.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Anoikis
/
Neoplasm Invasiveness
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2015
Type:
Article
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