Expression and clinical significance of nuclear factor κB/B cell lymphoma-2 signal pathway and glycogen synthase kinase 3β in oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 11-15, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-261147
ABSTRACT
<p><b>OBJECTIVE</b>This study aims to examine the expression of nuclear factor κB (NF-κB)/B cell lymphoma-2 (Bcl-2) signal pathway and glycogen synthase kinase 3β (GSK-3β) in oral squamous cell carcinoma (OSCC) and provide references for the early diagnosis and prognosis evaluation of OSCC.</p><p><b>METHODS</b>A total of 55 cases of OSCC and 10 cases of paracan- cerous mucosa were examined in this study. Their expressions of GSK-3β, NF-κB and Bcl-2 were detected using the SP me- thod immunohistochemistry. The correlation between their expression in OSCC and the clinical and pathological peculiarity of OSCC was analyzed.</p><p><b>RESULTS</b>The positive expression of GSK-3β, NF-κB, and Bcl-2 in OSCC were significantly higher than that in paracancerous mucosa (P < 0.01). The expression of GSK-3β, NF-κB, and Bcl-2 had no obvious relationship with patient's age, sex, and clinical stages of the disease (P > 0.05). The expression of Bcl-2 was significantly correlated with the degree of tumor differentiation (P < 0.05), whereas the expression of GSK-3β and NF-κB in OSCC had no obvious relation- ship with the degree of tumor differentiation (P > 0.05). Strong positive correlations were observed among the expressions of GSK-3β, NF-κB, and Bcl-2 (P < 0.05).</p><p><b>CONCLUSION</b>The positive expression of GSK-3β, NF-κB, and Bcl-2 in OSCC are sig- nificantly higher than that in paracancerous mucosa. Detecting GSK-3β, NF-κB, and Bcl-2 in OSCC may have implications in the early diagnosis and prognosis evaluation of OSCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mouth Neoplasms
/
Signal Transduction
/
Cell Differentiation
/
Lymphoma, B-Cell
/
NF-kappa B
/
Glycogen Synthase
/
Apoptosis
/
Neoplasms, Squamous Cell
/
Glycogen Synthase Kinase 3
Type of study:
Prognostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2015
Type:
Article
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