Research advances in gene polymorphisms in biological pathways of drugs for asthma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 567-573, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-261189
ABSTRACT
The studies on gene polymorphisms in biological pathways of the drugs for the treatment of asthma refer to the studies in which pharmacogenetic methods, such as genome-wide association studies, candidate gene studies, genome sequencing, admixture mapping analysis, and linkage disequilibrium, are used to identify, determine, and repeatedly validate the effect of one or more single nucleotide polymorphisms on the efficacy of drugs. This can provide therapeutic strategies with optimal benefits, least side effects, and lowest costs to patients with asthma, and thus realize individualized medicine. The common drugs for asthma are β2 receptor agonists, glucocorticoids, and leukotriene modifiers. This article reviews the research achievements in polymorphisms in biological pathways of the common drugs for asthma, hoping to provide guidance for pharmacogenetic studies on asthma in future and realize individualized medicine for patients with asthma soon.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacogenetics
/
Asthma
/
Leukotrienes
/
Polymorphism, Single Nucleotide
/
Therapeutic Uses
/
Drug Therapy
/
Metabolic Networks and Pathways
/
Precision Medicine
/
Adrenergic beta-2 Receptor Agonists
/
Genetics
Type of study:
Practice guideline
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Type:
Article
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