Roles of interleukin-21 and its receptor in autoimmune diseases / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 466-471, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-261208
ABSTRACT
Interleukin-21 (IL-21) is a new member of the interleukin-2 family. It is mainly synthesized and secreted by the activated of CD4(+) T cells and natural killer T cells. IL-21 receptor (IL-21R) is mainly expressed in T cells, B cells, and natural killer (NK) cells. After binding to its receptor, IL-21 can regulate the activation and proliferation of T cells, B cells, and NK cells through activating JAKs-STATs signaling pathways. As a new immunoregulatory factor, IL-21 and its receptor play important roles in the development and progression of various autoimmune diseases. Regulation of the expression levels of IL-21 and IL-21R and blocking of their signal transduction pathways with blockers may be new treatment options for autoimmune diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Autoimmune Diseases
/
Dendritic Cells
/
Killer Cells, Natural
/
Lymphocytes
/
Interleukins
/
Allergy and Immunology
/
Receptors, Interleukin-21
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Type:
Article
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