Changes in ambulatory electrocardiographic findings after oral administration of low-dose propranolol in infants with hemangioma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 345-349, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-261231
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of oral administration of low-dose propranolol on heart rate variability (HRV), acceleration capacity (AC), deceleration capacity (DC), and cardiac conduction in the treatment of infantile hemangioma.</p><p><b>METHODS</b>A total of 118 infants with hemangioma (≤1 year) were enrolled, and 24-hour ambulatory electrocardiography was performed before oral administration of low-dose propranolol and after one month of administration. The changes in time-domain indices [standard deviation of all normal sinus RR intervals (SDNN), standard deviation of all mean 5-minute RR intervals (SDANN), root mean squared successive difference (RMSSD), and percentage of successive normal sinus RR intervals >50 ms (PNN50)] and frequency-domain indices [low frequency (LF) and high frequency (HF)] for HRV, AC, and DC were observed, as well as abnormalities in cardiac conduction and other aspects after administration of propranolol.</p><p><b>RESULTS</b>After administration of propranolol, the infants had significantly increased SDNN, RMSSD, LF, HF, and PNN50 (P<0.01), and significantly reduced AC, mean heart rate (HR) and minimum HR (P<0.01). The 24-hour ambulatory electrocardiographic findings showed a nonsignificantly higher abnormal rate after administration of propranolol.</p><p><b>CONCLUSIONS</b>In the treatment of infantile hemangioma, propranolol can inhibit the activity of sympathetic nerve and block cardiac conduction, but without any serious adverse effect.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Propranolol
/
Administration, Oral
/
Therapeutic Uses
/
Drug Therapy
/
Electrocardiography
/
Heart Rate
/
Hemangioma
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Type:
Article
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