Exploration of acute graft versus host disease and its risk factors after allo-hematopoietic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 61-63, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-261361
ABSTRACT
<p><b>OBJECTIVE</b>To explore the incidence, prognosis and risk factors of the acute graft versus host disease (aGVHD) after allo-hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>The clinical data of 118 cases undergone 120 times of allo-HSCT were analyzed.</p><p><b>RESULT</b>aGVHD was observed in 63 cases (52.57%) including 17 severe cases (14.17%). The patients with aGVHD had a poor outcome, the 2-year overall survival rates were 61.40%, 64.08% and 17.65% for the non aGVHD, mild (degree I-II) and severe (degree III-IV) aGVHD groups respectively (P < 0.01). However, the relapse rates were 12.48%, 20.53% and 0% with no statistic significance. Unrelated transplantation and HLA-mismatch were the risk factors for aGVHD.</p><p><b>CONCLUSION</b>aGVHD is a common complication after allo-HSCT, the earlier it takes place, the poorer the prognosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Time Factors
/
Transplantation, Homologous
/
Severity of Illness Index
/
Survival Analysis
/
China
/
Acute Disease
/
Epidemiology
/
Incidence
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2003
Type:
Article
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