Expression of cell adhesion molecules in acute leukemia cell / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 581-584, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-261396
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of cell adhesion molecule in the development and extramedullary infiltration (EI) of acute leukemia.</p><p><b>METHODS</b>The expressions of neural cell adhesion molecule (NCAM) gene, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) genes in 25 acute leukemia patients bone marrow cells were detected by microarray and reverse transcriptase-polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>The expressions of NCAM, ICAM-1 and VCAM-1 gene were significantly higher in acute leukemia cells and leukemia cells with EI than in normal tissues and leukemia cells without EI, respectively, both by cDNA microarray and by RT-PCR.</p><p><b>CONCLUSION</b>The cDNA microarray is a powerful technique in analysis of acute leukemia cells associated genes. High expressions of cell adhesion molecule genes might be correlated with leukemia pathogenesis and infiltration of acute leukemia cell.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Bone Marrow Cells
/
Leukemia, Myeloid
/
Cell Adhesion Molecules
/
Gene Expression Regulation, Neoplastic
/
Acute Disease
/
Intercellular Adhesion Molecule-1
/
Vascular Cell Adhesion Molecule-1
/
Neural Cell Adhesion Molecules
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2002
Type:
Article
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