Value of cardiopulmonary exercise test in assessment of cardiac function of patients with pulmonary hypertension / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 497-500, 2013.
Article
in Zh
| WPRIM
| ID: wpr-261524
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of peak oxygen consumption in assessment of heart function of patients with pulmonary hypertension.</p><p><b>METHODS</b>From September 2010 to April 2012, 101 patients [29 male, mean age: (32.6 ± 11.4 )years] with pulmonary hypertension diagnosis by right heart catheterization were enrolled. Correlations among peak oxygen consumption, New York Heart Association (NYHA) class, NT-proBNP, 6 minute walking distance (6MWD) and cardiac index are analyzed.</p><p><b>RESULTS</b>There were 44 cases with NYHA class II (43.6%), 49 cases with NYHA class III (48.5%), mean 6MWD was (421 ± 91 )m, NT-proBNP was (1262 ± 816) ng/L, pulmonary vascular resistance was (1031 ± 582) dyn·s(-1)·cm(-5), CI was (3.5 ± 2.3) L·min(-1)·m(-2), peak oxygen consumption was( 13.8 ± 4.1)ml·min(-1)·kg(-1). 6MWD, pulmonary vascular resistance and peak oxygen consumption were related to CI (r = 0.299, -0.541, 0.341, respectively, all P < 0.05), but NYHA class and NT-proBNP were not correlated to CI. Multiple regression analysis demonstrated that peak oxygen consumption (B = 0.135, P = 0.004) but not 6MWD was correlated with CI after adjusting age, sex and pulmonary vascular resistance. ROC analysis found that the sensitivity and specificity using peak oxygen consumption <15.2 ml·min(-1)·kg(-1) as a cut-off value was 92.6% and 57.5%, respectively, for diagnosing severe heart dysfunction.</p><p><b>CONCLUSIONS</b>The correlation between peak oxygen consumption and CI is better than that of NYHA class, 6MWD, and NT-proBNP with CI. Peak oxygen consumption less than 15.2 ml·min(-1)·kg(-1) could be used to detect reduced CI in patients with pulmonary hypertension.</p>
Full text:
1
Index:
WPRIM
Main subject:
Oxygen Consumption
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Peptide Fragments
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Blood
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Natriuretic Peptide, Brain
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Diagnosis
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Exercise Test
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Heart
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Hypertension, Pulmonary
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Metabolism
Type of study:
Diagnostic_studies
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2013
Type:
Article