Research on the association between different levels of serum iron and essential hypertension / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the relationship between serum iron(SI) and essential hypertension (EHT) based on population-based samples.</p><p><b>METHODS</b>Using clustering multistage sampling method, all the people above 18 years old in the target population were investigated. Blood pressure was measured and the questionnaire was used to find out related factors. Five milliliters fast vein blood were drawn and the serum were used for testing on serum iron (SI) and other elements such as blood sugar, cholesterol (CHOL), triglyceride (TG), high density lipoprotein(HDL-C), low density lipoprotein (LDL-C), serum sodium, serum potassium, serum calcium etc. A case control study was carried out with EHT patients from the selected population as case group, and the other healthy peoples as controls. Database was created by Fox Pro and SPSS 10.0 was used for statistical analysis.</p><p><b>RESULTS</b>The concentrations of SI, with (17.75 +/- 7.66) micromol/ L in EHT group and (17.23 +/- 7.83) micromol/L in control group, showed statistical difference (P < 0.05) between the two groups. The concentrations of SI also showed statistical difference (P < 0.05) between the high DBP and normal group with the average level as (17.84 +/- 7.58) micromol/L in high DBP group and (17.26 +/- 7.85) micromol/L in normal group. Data from monovariate analysis showed that the increase of SI was a risk factor for EHT, DBP and SBP. By multivariate analysis for EHT, while SI still existed in the model (OR = 1.296, 95% CI 1.057-1.590), but for SBP the results almost remained the same (OR = 1.285, 95% CI1.102-1.498).</p><p><b>CONCLUSION</b>Data from the results showed that SI was probably a risk factor for EHT.</p>