Leiomyosarcoma with prominent osteoclast-like giant cells: a clinicopathologic analysis of 7 cases and review of literature / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 363-367, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-261776
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features of leiomyosarcoma with prominent osteoclast-like giant cells.</p><p><b>METHODS</b>The clinical and pathologic features of 7 cases of leiomyosarcoma with prominent osteoclast-like giant cells were analyzed. Immunohistochemical and ultrastructural studies were performed. The literature was reviewed.</p><p><b>RESULTS</b>All cases occurred in adults, with a mean age of 63 years. There was no significant sex predilection (male-to-female ratio = 43). The tumor involved subcutaneous soft tissue of thigh (number = 2), left back (number = 1), retroperitoneum (number = 1), small intestine (number = 1), breast (number = 1) and uterus (number = 1). Histologic examination showed that the tumor was composed of relatively uniform spindly cells arranged in interlacing fascicles. The hallmark was the presence of prominent osteoclast-like giant cells, either intimately admixed with the spindly cells (number = 6) or forming giant cell tumor-like nodules (number = 1). Immunohistochemically, the spindly cells expressed smooth muscle actin, muscle-specific actin, desmin and h-caldesmon in various degrees, whereas the osteoclast-like giant cells expressed CD68. Ultrastructural study showed smooth muscle differentiation in the spindly cells and histiocytic differentiation in the osteoclast-like giant cells. Follow-up data were available in 6 cases. There were local recurrences and/or metastases in all the 6 patients. Three patients were alive with unresectable or recurrent/metastatic disease and two patients died of the disease.</p><p><b>CONCLUSIONS</b>Leiomyosarcoma with prominent osteoclast-like giant cells is a rare variant of leiomyosarcoma which should be distinguished from the so-called giant cell variant of malignant fibrous histiocytoma. The osteoclast-like giant cells are of histiocytic differentiation. Surgical resection remains the mainstay of management of this high-grade sarcoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoclasts
/
Pathology
/
Retroperitoneal Neoplasms
/
Soft Tissue Neoplasms
/
General Surgery
/
Thigh
/
Back
/
Uterine Neoplasms
/
Vimentin
/
Calmodulin-Binding Proteins
Type of study:
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS