Progress of studies on microenvironment of lymphoma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1310-1313, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-261878
ABSTRACT
Many studies indicate that lymphoid neoplasms are related with chromosome translocations and the molecular alterations involving in the cell cycle and/or apoptotic pathways. However, survival of B and T tumor cells also depends on interactions of these cells with the accompanying cells comprising the lymphoma microenvironment. Immune cells, stromal cells and numerous molecular together make up the microenvironment and have functional interaction with tumor cells, promoting tumor growth and drug resistance. Different types of lymphoma have various clinical courses, therapy responses and prognoses, which show a close relationship with the microenvironment. This review summarizes several components of lymphoma microenvironment including macrophages, adhesion molecules and chemokines and the roles of microenvironment in classic non-Hodgkin's lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, suggesting that the microenvironment influence the prognosis of lymphoma, targeting microenvironment may be a potential method in lymphoma therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Cell Adhesion Molecules
/
Cell Cycle
/
Apoptosis
/
Chemokines
/
Tumor Microenvironment
/
Lymphoma
/
Macrophages
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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