Expression of DNA-dependent protein kinase catalytic subunit in adult acute leukemia and its significance / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1180-1183, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-261905
ABSTRACT
This study was aimed to explore the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in adult acute leukemia and its correlation with clinical characteristics, karyotype and prognosis. Indirect immunofluorescent cytometry was used to detect the expression of DNA-PKcs in bone marrow mononuclear cells of 105 patients with acute leukemia before chemotherapy and 41 of them after 2 cycles of chemotherapy. Cytogenetic data were obtained from 26 of them by R band karyotypic analysis. The results showed that the expression of DNA-PKcs was correlated with higher WBC count level in peripheral blood (p < 0.05), but was not obviously associated with median age, gender, percentage of bone marrow blasts, clinical classification, median hemoglobin level and median platelet count (p > 0.05). The middle and strong positive expression of DNA-Pkcs in non-remission group was significantly higher than that in remission group (p < 0.05). The positive rate of DNA-PKcs in abnormal chromosome group was significantly higher than that in chromosome normal group (p < 0.05). It is concluded that the DNA-PKcs expression level is closely related with the increased WBC count, and the expression of DNA-PKcs is correlated also with karyotype and clinical prognosis in adult acute leukemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Nuclear Proteins
/
Leukemia
/
Chromosome Aberrations
/
Diagnosis
/
DNA-Activated Protein Kinase
/
Karyotype
/
Genetics
/
Metabolism
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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